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Apply Anti-Wrinkle Cream 0.1% 2-3 nights a week to begin with. Gradually increase usage to every other night. Use about a pea-size amount of cream and apply to face, careful to avoid the eye and mouth areas of the face. Redness and peeling are normal within the first 2-4 weeks of usage. It can make the skin more sensitive to sunlight, so it is also recommended to wear a sunscreen in the morning when using this product.